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However, one should also keep in mind, that p53, generally activated in cellular stress controls, is also involvedbesides controlling the above mentioned metabolic pathwaysin other cellular key processes, like apoptosis, autophagy and cell proliferation through inhibition of Akt and mTOR (Liang et al., 2013)

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Moreover, ROS-dependent angiogenesis can be induced through the activation of this pathway to lead to the expression of HIF1 and VEGF [45]

It is characterized by a sustained systolic blood pressure (SBP) of 130 mmHg or higher, or a diastolic blood pressure (DBP) of 80 mmHg or higher