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Ferroptosis as a promising therapeutic strategy for melanoma

This compartment-specific metabolism stems from the differential expression of acyl-CoA synthetase short-chain family isoforms: isoform 1 (mitochondrial) and isoform 2 (cytosolic/nuclear) (Fig

Oncogene 30 , 5464 (2011)

382,383 An in-depth understanding of the underlying mechanisms of cellular pyroptosis is essential to determine its role in the pathogenesis of DPN and develop effective therapeutic agents targeting the pyroptosis signaling pathway to alleviate neuropathic symptoms

It outlines intervention categories, specific agents or approaches, mechanisms or molecular targets, study stage and model system, and observed immunological and therapeutic outcomes