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In addition, although our mechanistic gain- and loss-of-function studies were supported by extensive in vivo validation, part of the functional characterization was performed using HL60-derived neutrophil cells

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In the study, purified aspalathin from a fermented rooibos extract increased dose-dependently and significantly the glucose uptake by L6 myotubes at concentrations of 1-100 M, irrespective of insulin absence and also increased insulin secretion from cultured RIN-5F cells at 100 M