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One major limitation is the incomplete knowledge of the metabolic pathways and transformations that polyphenols undergo after ingestion, particularly due to interactions with the gut microbiome and the formation of diverse metabolites whose biological activities are not well characterized (119)

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High-fiber diet significantly alters the composition of the gut microbiota, leading to a large increase in the number of beneficial bacteria such as Lactobacillus and Bifidobacterium (29)

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GSK3 serves as a key kinase in the hyperphosphorylation of the microtubule-associated protein tau, thereby contributing to neuronal dysfunction and degeneration [91, 92]