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Following the completion of the procedures, all mice successfully emerged from anesthesia without any complications

Ipamorelin is a pentapeptide ghrelin mimetic that acts on the GHSR1a receptor, selectively stimulating GH secretion without significantly affecting cortisol, prolactin, or ACTH [4] [7]

Weiyong Li funded the successful completion of this experiment.All authors reviewed the manuscript. Electronic supplementary material Below is the link to the electronic supplementary material

The analogy sometimes used in the research literature: if endogenous GH release is like pressing both the accelerator (GHRH pathway) and releasing the brake (ghrelin pathway) simultaneously, the CJC/Ipamorelin combination approximates this dual-signal effect more closely than single-agent stimulation