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Elevated SAH inhibits many methyltransferases and lowers effective methylation potential

S-glutathionylation in sub-cellular compartments Regulation through S-glutathionylation has been ascribed to a large number of proteins that can be aligned into different functional clusters including, cytoskeletal, glycolysis/energy metabolism, kinase and signaling pathways, calcium homeostasis, antioxidant enzymes and protein folding

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This modulation influenced microbial metabolism and peripheral inflammation, regulated the activation state and functionality of microglia, and thereby reduced neuroinflammation and amyloidosis

To confirm whether the evicted entity corresponds to TRF1, we analysed the full shelterin complex by SDS-PAGE, upon co-incubation with increasing amounts of compound 40 or control compound 60 and subsequent mild crosslinking, analogous to the mass photometry experiment