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doi: 10.1016/j.reprotox.2020.06.012 22 WuWChenYGuoWZhangKChenWFuMet al

In PEM, there are insufficient building blocks and energy to make immune cells and immune factors that protect the body from infection and disease

Moreover, another study has demonstrated the combined anti-cancer and immunomodulatory effects of methotrexate loaded in a PLGA carrier covered with polyethyleneimine and hyaluronic acid against a breast cancer mouse model [182]