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Neuro Oncol (2022) 24(2):197209

In keeping with this, pioglitazone, a peroxisome proliferator-activated receptor ligand that improves natural antioxidant defences (including frataxin), is presently being under trial in our hospital in France (two-year phase III trial ending in 2013)

By screening appropriately and choosing compounds based on both mechanism and medical history, we can maximize regenerative benefits while minimizing oncologic risk

Moreover, it also showed biosafety for long-term administration