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Injection into sensitive or low-fat tissue: Areas such as the abdomen, inner thigh, or other sites with minimal subcutaneous fat have less tissue cushioning and a higher density of sensory nerve endings, making pH-related discomfort more noticeable

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Depurination of the N3Ade adduct is instantaneous, whereas depurination of the N7Gua adduct occurs rather slowly [15, 23, 2729]

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