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2.4 Elevated GPATCH3 expression correlates with poor prognosis in human cancers and in mouse xenografts Pan-cancer transcriptomic analysis using GEPIA2 (33) revealed that GPATCH3 is significantly upregulated in a broad spectrum of malignancies compared to corresponding normal tissues ( Figure 4A )

Some other alkaloids, such as the alkaloid leonurine extracted from Leonurus heterophyllus (0.2 mg/kg for 7 days), showed a high ability to protect mitochondria and prevent ROS generation and reduce cytochrome c levels in vivo [145]

doi: 10.1016/j.immuni.2011.06.015 159 GhoneimHEFanYMoustakiAAbdelsamedHADashPDograPet al

doi: 10.3389/fcimb.2024.1279220 Received 19 August 2023 Accepted 22 January 2024 Published 15 February 2024 Volume 14 - 2024 Edited by Lionel Breton, IDEC Therapeutic/CILIA Consult, France Reviewed by Xiang Wang, Nanjing University, China Mohammad Alrashdan, University of Sharjah, United Arab Emirates Ioanina Parlatescu, Carol Davila University of Medicine and Pharmacy, Romania Updates Copyright 2024 Wu, Bai, Jing and Chen

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