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In neurodegenerative diseases, persistent DNA damage overwhelms the repair mechanisms, causing genomic instability and triggering apoptotic pathways [129,130]

revealed that administration of VC improves the sputum conversion culture rate in RIF-susceptible Mtb-infected patients (189)

One way to correct for confounding is stratification

In normoxia, hydroxylation of HIF- by PHDs enables its interaction with pVHL (von Hippel-Lindau protein) and targets subunits for ubiquitination and proteasomal degradation [140]