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If these goals are not achieved within a certain time span, the ER stress triggers apoptosis, programmed cell death

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3.5.1 Inhibition of bEV virulence activity and destruction of bEV integrity Therapeutic strategies that demonstrate the ability to impact the integrity of bEVs and/or hinder the functions of their virulence factors have shown promise

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However, its explicit role in the Y-H transition is yet to be explored [121]