Mitochondrial DNA Depletion Syndrome As an autosomal recessive disease, mitochondrial DNA depletion syndrome (MDS) is characterized by severe reduction in mtDNA content in the affected tissues and organs (45)
Key dosing points from the study: Dose range: 200500 mcg per session (individual variation based on severity and body weight) Frequency: 23 sessions per week during the active treatment phase Duration: 48 weeks of active treatment Route: Local subcutaneous injection proximal to the affected joint Concurrent therapy: Most patients continued physical therapy alongside BPC-157 treatment The combination of local administration and physical therapy aligns with the hypothesis that BPC-157 accelerates structural repair while functional loading (exercise) guides proper tissue remodeling
In univariable analysis (exp, 95% IC, p) female sex was associated with smaller core (0.571, 0.448-0.729, 6 H) Agathe Sadeler 1 , Stefanos Finitsis 2 , Jean Marc Olivot 3 , Sbastien Richard 4,5 , Gaultier Marnat 6 , Igor Sibon 7 , Lionel Calviere 3 , Christophe Cognard 8 , Mikael Mazighi 9,10,11,12 , Jean Philippe Desilles 9,11,12,13 , Bertrand Lapergue 14 , Ruben Tamazyan 1,13 , Mathieu Zuber 1,11,13 , Benjamin Gory 15,16 , Benjamin Maer 1,9,11,12 1 Neurology Department, Hpital Saint-Joseph, Paris, France, 2 Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece, 3 Vascular Neurology Department, CIC 1436, University Hospital of Toulouse, Toulouse, France, 4 Department of Neurology, Stroke Unit, Universit de Lorraine, CHRU-Nancy, Nancy, France, 5 CIC-P 1433, INSERM U1116, CHRU-Nancy, Nancy, France, 6 Department of Diagnostic and Interventional Neuroradiology, University Hospital of Bordeaux, Bordeaux, France, 7 Neurology Department, University Hospital of Bordeaux, Bordeaux, France, 8 Department of Neuroradiology, CHU Toulouse, Toulouse, France, 9 Interventional Neuroradiology Department, Hpital Fondation A
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