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This work was supported in part by Japan Cancer Society Relay For Life My Oncology Dream Award (HA), The Mochida Memorial Foundation for Medical and Pharmaceutical Research (HA), The Uehara Memorial Foundation Research Fellowship (HA), TRIUMPH fellowship in the Cancer Prevention Research Institution of Texas (CPRIT) Training Program RP210028 (EA), Paul & Mary Haas Chair in Genetics (MA), NIH/NCI R41 CA275631 (MA), FDA R01 FD006118 (MA and JI) Leukemia SPORE P50 CA100632 Development Research Program (MA and JI), MD Anderson Multidisciplinary Research Program (MA and JI), MD Anderson Cancer Center Institutional Research Grant (JI), the Department of Defense CA220581 (JI), New Investigator Research Grant Program from Leukemia Research Foundation (JI), and various donor funds (MA)

Therefore, future research must, while promoting translation, deeply dissect the dual roles of MR in different immune microenvironments to mitigate potential risks

But when they become hyper-responsive, mast cells may release these chemicals too easily, too intensely, or at random

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