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With poorly controlled or severe disease, there is risk that extra-articular manifestations such as keratitis, pulmonary granulomas (rheumatoid nodules), pericarditis/pleuritis, small vessel vasculitis, and other non-specific extra-articular symptoms will develop

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DOI: org/10.1161/01.RES.79.6.1143 13

Proc Am Assoc Cancer Res 43:1099, 2002