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3.2 Role of TGF- in radiation skin fibrosis TGF- is a cytokine intricately involved in the fibrotic process across various organs and tissues ( 3.2.1 TGF- Signaling and cellular mechanisms in radiation-induced fibrosis TGF- exerts its effects through the activation and proliferation of fibroblasts, leading to ECM accumulation ( TGF- expression is dose-dependent on radiation exposure, binding to its receptors to form a trimeric complex which can lead to tissue fibrosis ( Figure 2 )

Calabrese V, Di Maio A, Marino G, Cardinale A, Natale G, De Rosa A, Campanelli F, Mancini M, Napolitano F, Avallone L et al (2020) Rapamycin, by Inhibiting mTORC1 Signaling, Prevents the Loss of Striatal Bidirectional Synaptic Plasticity in a Rat Model of L-DOPA-Induced Dyskinesia

Disclosures: Akash Shukla: Nothing to Disclose, Shashank Pujalwar: Nothing to Disclose, Shubham Gupta: Nothing to Disclose, Yash Kallurwar: Nothing to Disclose, Arun Vaidya: Nothing to Disclose 2277 DETERMINANTS AND IMPACT OF IMPAIRED AEROBIC CAPACITY ON SURVIVAL IN PATIENTS WITH CIRRHOSIS: RESULTS FROM A 2600 PATIENT COHORT William Bernal 1 Sarah Brown 1 Sameer Patel 1 Pervez Khan 1 Robert Loveridge 1 Abid Suddle 1 Varuna Aluvihare 1 , 1 Institute of Liver Studies, Kings College Hospital, London UK Background: Aerobic capacity quantified using maximal oxygen uptake (VO2 max) at cardio-pulmonary exercise testing (CPET) is often impaired in cirrhotic chronic liver disease (CLD) and impacts survival

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