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In HaCaT model, quercetin treatment was associated with increased expression of E-cadherin and occludin, upregulation of antioxidant enzymes including superoxide dismutase 1 (SOD1) and superoxide dismutase 2 (SOD2) and catalase, and reduced levels of pro-inflammatory cytokines and matrix metalloproteinases (MMPs), which may support improved keratinocyte migration and in vitro wound closure (Beken et al., 2020)

It also brought the SOD, catalase, GPx, and GSH levels to normal and decreased lipid peroxidation in the kidney and liver of streptozotocin-induced diabetic rats

Studies show that glutathione prevents hyperpigmentation at the cellular level by interrupting melanin enzymes at the skins surface so they dont develop into dark spots

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The regulatory effects of Citrus peel powder on liver metabolites and gut flora in mice with non-alcoholic fatty liver disease (NAFLD)