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This restoration of the cellular powerhouses leads to a gradual increase in ATP production

doi: 10.3389/fpsyt.2025.1589663 Received 10 March 2025 Accepted 06 May 2025 Published 29 May 2025 Volume 16 - 2025 Edited by Paulo Santos, University of Porto, Portugal Reviewed by Martn Garca Juarez, Autonomous University of Nuevo Len, Mexico Gayane Vardanyan, Yerevan State Medical University, Armenia Updates Copyright 2025 Luan, Wang, Shi, Zhang, Wang, Zhou, Wu, Liu, Li, Zhang, Shao, Chen, Chu and Wei

The exchange of glutamate, glutamine, and GABA between neurons and astrocytes is mediated by the glutamate(GABA)glutamine cycle, which is critical for maintaining excitatory and inhibitory neurotransmission and preventing excitotoxicity 27,73,429,430

On the same line of evidence, supplementation of cells of neuronal origin with a membrane permeable GSH derivative (GSH60) protects them from NO neurotoxicity (Hu et al., 2012)