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doi: 10.1016/j.cbi.2018.08.027

It can be viewed as a progressive age-related decline in physiological systems, leading to a reduction in intrinsic capacity reserves, making people highly vulnerable to stress and increasing the risk of a range of adverse health outcomes (178)

10.1007/s10068-018-0324-2 Food Sci

This influence includes the regulation of adrenergic receptor expression, particularly the up- and down-regulation of alpha-2 and beta-2 receptors, which may contribute to the hypotensive effects of melatonin on the eyes (65)