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An 18-month study in mice and a lifetime study in hamsters revealed no evidence of tumorigenicity

38,39 These failures may be attributed in part to flaws in study design, such as imbalance in patient baseline across treatment arms and lack of specific participant eligibility criteria, but may also be due to the structure of the agents themselves being less active in humans and presenting off-target toxicity

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10.7150/ijbs.90808 198 XuW.JanochaA