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Advances in chitosan-based microcapsules and their applications

Achieving site-specific transcranial drug delivery to closed-skull TBI patients may be more difficult than the authors imply: the subarachnoid space filled with circulating cerebrospinal fluid (CSF) is about 3-4 mm deep in humans (3), more than an order of magnitude deeper than in mice, permitting CSF to quickly remove drug molecules from a targeted cortical site

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However, 2D models fail to mimic the main ECM where ECs grow in vivo and the development of the glycocalyx is unknown in this type of culture [87]

These factors, combined with the portability and accessibility of ultrasound systems, render it especially appropriate for cervical DRG interventions This case report explores the synergistic effects of combining PRF therapy with ultrasound-guided perineural Vitamin B12 injection targeting the C2 DRG in a patient with refractory C2 PHN