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Several factors can lead to c spine impingement and nerve root compression: Age-Related Changes Cervical disc degeneration : Discs lose height and elasticity over time Bone spurs (osteophytes) : Extra bone growth that narrows nerve pathways Facet joint arthritis : Joint inflammation that can compress nearby nerves Acute Injuries Herniated discs: When disc material pushes out and presses on nerve roots Cervical strain : Can cervical strain cause radiculopathy

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Step 4 : 3 rd Chromatography step Fig.4

doi: 10.3389/fimmu.2019.01187 24 TakasoYNodaMHattoriTRoboonJHatanoMSugimotoHet al