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In a prospective trial of 24 subjects, a clinic RF microneedling device produced a statistically significant reduction in periorbital wrinkle severity, with the aggregated facial wrinkle score falling by roughly half over the study

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Animal and cell-culture studies point to three overlapping pathways: promotion of angiogenesis (new blood-vessel formation, linked to VEGF), support for collagen and tendon repair, and anti-inflammatory effects