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Interestingly, repeated NFT treatment resulted in higher GCLC levels in the days after removal of the compound and an elevated induction in response to a second exposure to NFT, similar to the previously published pattern of sulfiredoxin synthesis upon repeated exposure to DEM or tert -butylhydroquinone (Bischoff et al

528,529 Metformin, a traditional diabetes drug, upregulated the expression of mitophagy genes, such as PINK , Parkin , and Mfn2 , while at the same time effectively reducing damaged mitochondria after administration, indicating a great potential of metformin as a mitophagy activator

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Xiong JQ, Zhao CY, Qin JY, Cui P, Zhong QL, Ru S (2022) Metabolic perturbations of Lolium perenne L

As a result, it promotes a lighter, more even skin tone over timewithout harsh bleaching agents