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however, it is important to note that this treatments effects have often been temporary, and have not been successful in every case

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Induction of the unfolded protein response by -synuclein in experimental models of Parkinsons disease

Particularly noteworthy is that FOXO4 influences not only lifespan but also the quality of aging through its interaction with the protein p53commonly referred to as the "guardian of the genome." This interaction regulates whether cells remain in a senescent, metabolically inactive state or undergo programmed cell death (apoptosis)