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Negative prognostic findings include older age, dullness, weakness, ptyalism, hypoproteinemia, hypoalbuminemia, elevated creatine kinase, hypocholesterolemia, hepatic failure at presentation, anemia, hypokalemia, and lack of aggressive nutritional and supportive care

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Today these evidence-based guidelines statements represent not absolute mandates but provisional proposals for treatment under the specific conditions described in each document

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