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In a previous study, HT was also reported to induce antioxidant enzymes and Nrf2 translocation via PI3K/Akt pathways in HepG2 cells [57]

doi: 10.1038/s41568-022-00459-0 131 ViswanathanVSRyanMJDhruvHDGillSEichhoffOMSeashore-LudlowB

However, due to challenges in colonization and the associated risk of infection, fecal microbiota transplantation and oral probiotics are not currently deemed safe or viable therapies for TNBC (267)

In vitro and in vivo Down syndrome models revealed that supplementation of mice with low molecular weight antioxidants such as -tocopherol reduced the level of oxidative stress, attenuated degeneration of cholinergic neurons, and improved working memory (Lockrow et al

These in vitro findings reveal potential mechanisms by which ferroptosis regulates bone remodeling, yet the pathological roles of osteoblasts and osteoclasts are fundamentally distinct