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Critical Reviews in Food Science and Nutrition, 63 (20), 46184635

Mitochondrial metabolism and homeostasis Mitochondrial dysfunction is a core feature of DACI (70), contributing to both the ROS production and iron dysregulation that drive ferroptosis

P-value below 0.05 is indicative of statistical significance

Mutations in ironsulfur cluster scaffold genes NFU1 and BOLA3 cause a fatal deficiency of multiple respiratory chain and 2-oxoacid dehydrogenase enzymes

But this makes our lungs particularly susceptible to injury due to the relatively high concentration of reactive oxygen species (ROS) which are produced by our normal metabolism