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O-GlcNAcomic profiling identifies widespread O-linked -N-acetylglucosamine modification (O-GlcNAcylation) in oxidative phosphorylation system regulating cardiac mitochondrial function

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A plethora of studies in humans have clearly demonstrated that estrogen promotes vasodilation through an eNOS-dependent mechanism (Miller and Mulvagh, 2007)

And these cells express lipid-associated genes (e.g., Trem2, Lpl, Apoe )

In a further study we investigated the anti-cancer effects of A009 on breast cancer cells (MDA-MB-231 and BT-549) when combined with chemotherapeutic agents such as doxorubicin, an anthracycline commonly used in breast cancer therapy, and 5-FU as the prototype fluoropyrimidine