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Life Sci 328:121814 Shen Z, Xiang M, Chen C, Ding F, Wang Y, Shang C, Xin L, Zhang Y et al (2022) Glutamate excitotoxicity: potential therapeutic target for ischemic stroke

elegans , where HLH-30 (ortholog of TFEB) regulates the expression of lysosomal triglyceride lipases ( Tfeb in mice (TFEB-Tg mice) leads to an improvement of glucose tolerance, insulin sensitivity, and weight gain in mice fed with high-fat diet and, importantly, to a lean phenotype that is abolished in an Atg7 -deficient background, genetically demonstrating the epistasis of TFEB and autophagy (Settembre et al., 2013)

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