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In addition, the study of a Mat1a KO-derived HCC cell line (SAMe-D) demonstrated that LKB1 regulates Akt (protein kinase B)-mediated survival through its hyperphosphorylation and also blocks the apoptotic response through phosphorylation and retention of p53 in the cytoplasm [112]

JAMA 291 , 844850 (2004)

While effective, this treatment is costly, not widely available, and can place significant stress on the liver and kidneys

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