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Once all chromosomes are correctly aligned and attached, the inhibition by the SAC is relieved, facilitating the equitable distribution of chromatids to daughter cells (26)

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4.6.8 Mitochondrial Function and Energy Metabolism Energy metabolism is dysregulated early in the course of ALS as a result of decreased appetite, increased energy expenditure, and hypothalamic dysfunction, among other complex factors [295,296,297,298,299]