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While B vitamins are water-soluble and are generally excreted in the urine when in excess, extremely large and repeated doses can overwhelm the body's ability to eliminate them efficiently

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However, some people may experience mild issues like nausea, diarrhea, or a temporary upset stomach

Doxycycline-inducible OSKM MEFs were cultured in normal iPS media with doxycycline without or without vitamin B12 supplementation as indicated

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