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Regulatory effect of hsa-miR-5590-3P on TGF signaling through targeting of TGF-R1, TGF-R2, SMAD3 and SMAD4 transcripts

For controls, the same procedure was performed without microglia, adding STEMdiff Microglia Differentiation medium cultured with HIV-1 JR-CSF viral inoculate (HIV-NO), heat-inactivated viral inoculate (HIV HI-NO) or mock inoculate (mock-NO)

Curcumin has reduced bioavailability, as the compound is absorbed in a precarious manner, rapidly metabolized, and eliminated from the body (Liu et al., 2016) (Fig