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( D ) Box plots of the mean change in MS between baseline and week 24 showed no significant improvement in cohort 1 (change = 0.17 dB, 95% CI: 0.62 to 0.96, P = 0.67) by linear mixed-effects model, but there were statistically significant improvements in mean MS between baseline and week 24 in cohort 2 (change = 0.33 dB, 95% CI: 0.020.64, P = 0.04) and cohort 3 (change = 0.85 dB, 95% CI: 0.291.42, P = 0.003)

The researchers found that IGF-1 levels were lower in diabetic women with vertebral fractures, suggesting IGF-1 as a marker for the severity of vertebral fractures [10]

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8 These seven clinical studies had varying designs and methodologies