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doi: 10.1016/j.ejphar.2022.174823 186 PandeyAVishnoiKMahataSTripathiSCMisraSPMisraVet al

Sterile liver injury induces a protective tissue-resident cDC1-ILC1 circuit through cDC1-intrinsic cGAS-STING-dependent IL-12 production

reported that MSDC-0602a novel insulin sensitizer acting as a direct mitochondrial pyruvate carrier inhibitorprevented and reversed liver fibrosis and inhibited stellate cell activation in mice livers fed a high-fat, high-fructose, high-cholesterol diet, and protected animals from developing MASH (McCommis et al