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As such, the maintenance of GSH and Prdx2 antioxidants are essential to protect the RBCs from these reactive oxygen species (ROS)

One small randomized controlled trial in 450 pregnant women in West Africa, without specified MTHFR genotype but at high risk for preeclampsia, found that supplementation with 15 mg of riboflavin daily was not effective in preventing the condition (29), but the study was likely underpowered to detect a significant effect

doi: 10.1111/nph.12494 78 LiuP.YinL.DengX.WangS.TanakaK.ZhangS

Interestingly, NAC exerts a GSH-supplementing effect in GSH-deficient cells, whereas this effect may be ineffective in GSH-enriched cells [101]

doi:10.4049/jimmunol.1102683