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Baer, et al., Thiols: Role in Oxidative Stress-Related Disorders (2021)

However, when the demand for ATP is lower than that for NAD + , this condition may result in damage to the ETC, which in turn may trigger increased O 2 production

These approaches aim not only to inhibit KRAS signaling directly, but also to eliminate oncogenic proteins or exploit vulnerabilities associated with KRAS-driven tumors