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Heliyon 7, e06648

This improvement determined a longer drug effect, and a better penetration into the brain in comparison with amphetamine, as well as less detrimental consequences on heart (Napper et al., 2010)

10.1093/eurheartj/ehx342 17

This suggests that lifestyle modifications may be necessary as an effective treatment for pillar pain, particularly for patients who are reporting higher pain levels even after all therapeutic options are exhausted