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Au et al., 2022b)

Figure 2 2.1.1 Effects on innate immune system Neutrophils are the most abundant leukocytes population in peripheral blood, and they exert their activity early during inflammation, releasing cytokines, proteases, producing reactive oxygen species (ROS), and creating neutrophils extracellular traps (NETs) (33) Neutrophils represent the main targets of A1AT action: being an anti-protease, its primary effect is to inhibit serine proteases deriving from degranulating neutrophils including NE, cathepsin G and PR3 (34)

5 Thyroid 5.1 Female 5.1.1 In vivo human studies Inhibition of the secretion of thyroid hormones is associated with its hypothyroidism

Fan Y, Su Q, Chen J, Wang Y, He S

Martinez FD, Antognoni G, Macri F, Bonci E, Midulla F, De Castro G, & Ronchetti R (1988) Parental smoking enhances bronchial responsiveness in nine-year-old children