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Synergy between parthenolide and arsenic trioxide in adult T-cell leukemia/lymphoma cells in vitro

The GSH/GSSG ratio serves as a primary determinant of the cellular redox state, as reduced GSH is thought to repair oxidative damage to protein thiols and to support redox signaling, the regulation of cell proliferation, control of the cell cycle, initiation of apoptosis, modulation ofthe immune response, and maintenance of skin pigmentation