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Unexplained fatigue that does not respond to foundational interventions, vague or migrating joint pain without clear orthopedic or infectious disease explanation, persistent low-grade inflammatory markers without obvious infection, skin changes including rashes, photosensitivity, or Raynauds phenomenon, and early or unexplained thyroid antibody elevation all warrant closer investigation

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doi: 10.1016/j.clinbiochem.2009.04.006

These regulators modulate ATG expression during fasting, feeding, lipid accumulation, and stress