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3) Glycaemic and cardiometabolic endpoints in defined populations Some cagrilintide combination studies include participants with type 2 diabetes and report glycaemic endpoints such as HbA1c alongside weight change

This helps raise the baseline energy threshold, potentially reducing the severity and duration of crashes following physical or cognitive exertion

Transgenic murine models for cognition Beyond chemical lesion models (scopolamine, 192-IgG-saporin), cognitive research has an arsenal of genetically modified strains that reproduce specific cognitive phenotypes: Alzheimer models 3xTg-AD (LaFerla): triple transgenic APP Swedish, PS1 M146V, tau P301L

In Rac1 conditional KO mice where Rac1 was deleted in mature neurons, working memory in the delayed matching-to-place (DMP) water maze test was impaired (Haditsch et al., 2009), implicating Rac1 in memory acquisition but not in memory consolidation