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Discovery of GBT440, an orally bioavailable R-state stabilizer of sickle cell hemoglobin

10.1093/jn/137.10.2196 21 NegmA.El-NeanaeyA

Conversely, nitric oxide synthase inhibitors reduced the SNO modification of Bcl-2, accelerated its degradation and promoted cell apoptosis through the activation of the cysteine protease family [151]

Consequently, elucidating the function of ubiquitination and deubiquitination modifications on glutamine metabolizing enzymes in tumor cells is anticipated to yield novel concepts for the formulation of novel clinical treatment strategies for tumor patients

Accordingly, the overexpression of rare tRNAs is a more economical means of optimization