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Berberine in obesity therapy: from molecular mechanisms to clinical applications

On one hand, STING activation has been shown to promote the differentiation of nave CD4 T cells into Th1 and Th9 cells and enhance the production of effector cytokines such as IFN- and IL-9, thereby augmenting CD4 T cell effector functions [229]

In thyroid cancer cells, it inhibits apoptosis through the inhibition of apoptosis signal-regulating kinase 1 (ASK1) activity (72), whereas in human hepatoma it suppresses the redox-dependent activation of caspases, inducing tumor necrosis factor- (TNF)-related apoptosis-inducing ligand (TRAIL) resistance (73)