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Kemampuannya untuk memodulasi ekspresi gen dan mengurangi peradangan menunjukkan bahwa ia dapat memainkan peran dalam memperlambat perkembangan penyakit Alzheimer atau aterosklerosis, sedangkan efek anti-tumornya (sebagaimana dibuktikan oleh penindasan gen yang berhubungan dengan kanker) memerlukan penyelidikan lebih lanjut

Phosphorylation of recombinant human ATP:citrate lyase by cAMP-dependent protein kinase abolishes homotropic allosteric regulation of the enzyme by citrate and increases the enzyme activity: allosteric activation of ATP:citrate lyase by phosphorylated sugars

These alterations are also evident in genetic research [25, 26] and transcriptomic studies [23, 27] indicating that altering monocyte activation or inhibiting monocyte entry into the central nervous system (CNS) decreases neuroinflammation and provides neuroprotection in preclinical PD models [28, 29]

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TLR7 agonism accelerates disease and causes a fatal myeloproliferative disorder in NZM 2410 lupus mice