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It was isolated from a naturally occurring protective protein in human gastric mucosa the stomachs inner lining which evolved over millions of years precisely to survive highly acidic, enzyme-rich environments

doi:10.1016/j.jaccao.2022.10.014

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It means that excess amounts are typically excreted through urine rather than accumulating to toxic levels , making vitamin B12 supplementation generally safe even at higher doses, though adverse reactions such as hypersensitivity or acneiform rash can occur rarely

Patients usually have a mix rather than just one