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doi: 10.1016/j.semcdb.2017.05.023 35 D'autreauxBToledanoMB

Under normal conditions, Kelch-like ECH associated protein 1 (Keap 1), which functions as an adaptor protein, is bound to Nrf2 and serves for Nrf2s continuous ubiquitylation and degradation, while under oxidative stress conditions, Keap 1 is inactivated resulting in the translocation of Nrf2 into the nucleus where the transcription of antioxidant genes begins (Baird et al