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This test should be repeated in a way that covers all the cycles involved and specific analysis on a subject-by-subject basis should be done to confirm what % of participants see calcium re-absorption into the bone and changes in the osteoclastic resorption phase

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Response: As readers are aware, we have been contemplating potential clinical APC assignments for the past number of rulemaking cycles but are not convinced as to what clinical APC would be appropriate in terms of clinical and resource homogeneity

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Nowak L, Bregestovski P, Ascher P, Herbet A, Prochiantz A (1984)