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Interstitial hypertension suppresses escape of human breast tumor cells Via Convection of interstitial fluid

34 In the present study, we observed that the hUC-MSCs treatment inhibited the expression of CD86 and iNOS and promoted the expression of CD206 in both liver tissues and RAW264.7 cells, which is consistent with previous reports stating that MSCs attenuated sepsis-induced liver injury by suppressing macrophage M1 polarization

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Some of these methods include, random mutagenesis, error-prone PCR, chemical mutagenesis, site-directed mutagenesis, and other methods well known in the art (for a comprehensive listing of current mutagenesis methods, see Maniatis, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, Cold Spring, N.Y